NAD+ 1000MG
NMN (Nicotinamide Mononucleotide)
NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in all living cells, essential for energy production and metabolic processes. It plays a vital role in the mitochondria, facilitating cellular respiration and the production of ATP, the cell’s main energy currency. NAD+ is also involved in DNA repair, gene expression, and cellular signaling. As we age, NAD+ levels decline, leading to reduced energy production, impaired cellular functions, and increased susceptibility to age-related diseases. Boosting NAD+ levels through supplements like NMN and NR has shown promise in enhancing energy metabolism, promoting healthy aging, and improving overall cellular health.
- Energy Production: NAD+ is essential for converting the food we eat into energy that our cells can use. This process happens in the mitochondria, the powerhouses of the cells.
- DNA Repair: NAD+ activates proteins called sirtuins, which help repair damaged DNA and keep our genes stable.
- Gene Regulation: Sirtuins, which rely on NAD+, also control the activity of certain genes, including those related to aging.
- Cell Communication: NAD+ is a key player in various cell signaling processes, helping cells communicate and respond to stress.
- Mills, K. F., Yoshida, S., Stein, L. R., et al. (2016). “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.” Cell Metabolism.
- Imai, S., & Guarente, L. (2014). “NAD+ and Sirtuins in Aging and Disease.” Trends in Cell Biology.
- Yoshino, J., Baur, J. A., & Imai, S. I. (2018). “Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice.” Cell Metabolism.
- Conze, D., Brenner, C., & Kruger, C. L. (2019). “Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Healthy Overweight Adults.” Scientific Reports.
- Baur, J. A., & Sinclair, D. A. (2006). “Therapeutic potential of resveratrol: the in vivo evidence.” Nature Reviews Drug Discovery.
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- Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011). “Resveratrol and health – A comprehensive review of human clinical trials.” Molecular Nutrition & Food Research.
- Baur, J. A., & Sinclair, D. A. (2006). “Therapeutic potential of resveratrol: the in vivo evidence.” Nature Reviews Drug Discovery.
- Hong, S., Moreno-Navarrete, J. M., Wei, X., et al. (2020). “Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.” Nature Medicine.
- Uhlenhaut, N. H., & Treier, M. (2016). “Nicotinamide N-Methyltransferase Inhibition Improves Muscle Insulin Sensitivity.” Cell Metabolism.
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