Semaglutide promotes weight loss by acting as a GLP-1 receptor agonist. It mimics the action of GLP-1, a hormone that regulates appetite and food intake. By activating GLP-1 receptors, Semaglutide reduces appetite and increases feelings of fullness, leading to lower calorie consumption. This combination of reduced appetite and increased satiety effectively helps in controlling food intake, thereby facilitating weight loss.